Fanning began acting at the age of five after appearing on a Tide commercial. Her first significant acting job was a guest-starring role in the NBC prime-time drama ER, which remains one of her favorite roles ("I played a car accident victim who has leukemia. I got to wear a neck brace and nose tubes for the two days I worked.")
Fanning subsequently had several guest roles on established television series, including CSI: Crime Scene Investigation, The Practice, and Spin City. She also portrayed the title characters of Ally McBeal and The Ellen Show as young girls. In 2001, Fanning was chosen to star opposite Sean Penn in the movie I Am Sam, the story of a mentally challenged man who fights for the custody of his daughter (played by Fanning).




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